Schizophrenia is characterized by three symptom domains and affects ~1% of global population. First and mostly known are the positive symptoms like hallucinations and delusions, secondly are negative symptoms like reduced emotion and lack of motivation and the third symptom domain is cognitive impairment like a poor memory or disorganized thinking. While there are already many drugs for treating positive symptoms, there is a significant unmet medical need for effective treatments for negative and cognitive symptoms.
