About Chronic Kidney Disease

The kidneys are one of the hardest-working organs in the body, where a million tiny filters called nephrons work together to filter the blood to convert waste products and excess fluid into urine.1 The progressive loss of kidney function over time is one aspect of chronic kidney disease (CKD).2

If the kidney function is lost, chronic kidney disease (CKD) develops. People with high blood pressure, diabetes, cardiovascular or metabolic diseases as well as people with a family history of CKD and older people have an increased risk of developing chronic kidney disease.6,7,8

CKD is a very common condition affecting more than 10 % of the global population. 3,4 Due to its silent nature, many people are undiagnosed. This means millions of people die prematurely from CKD and related complications every year.

What causes chronic kidney disease? 6,7,8

Certain people are at an increased risk of developing CKD. 5 This includes those:

  • living with metabolic conditions such as diabetes and high blood pressure
  • with a history of kidney conditions (e.g. infection, cysts or inflammation)
  • with a family history of CKD
  • who are older in age

 

What are the symptoms of chronic kidney disease? 9

When kidney disease first starts to develop, most cases are asymptomatic (no symptoms), but as damage to the kidneys worsens, symptoms can include: 

  • fatigue
  • swollen ankles, feet, or hands
  • shortness of breath
  • feeling sick
  • urinating more or less often than usual
  • itchy or dry skin

 

How is chronic kidney disease diagnosed?10

Professional guidelines recommend the use of two tests to diagnose CKD:

  1. blood test checks how well the kidneys are filtering blood, using a metric called estimated glomerular filtration rate (eGFR).
  2. urine test checks for both albumin and creatinine in the urine, known as an albumin-to-creatinine ratio (UACR).

People with high blood pressure, diabetes, and cardiovascular conditions are at higher risk of CKD and should be screened according to healthcare guideline recommendations. 

 

CKD Prevalence in Austria

Around 10% of the population have chronically impaired kidney function.11

This is roughly equivalent to the population of Salzburg and Vorarlberg.

CKD Prevalence in Austria

MPR-AT-100593

  1.  National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK): Your Kidneys and How They Work. Verfügbar auf: https://www.niddk.nih.gov/health-information/kidney-disease/kidneys-how-they-work#:~:text=Your%20kidneys%20remove%20wastes%20and,and%20potassium%E2%80%94in%20your%20blood. Accessed in February 2024.

  2.  Leon BM, Maddox TM. Diabetes and cardiovascular disease: Epidemiology, biological mechanisms, treatment recommendations and future research. World J Diabetes. 2015;6(13):1246–58.

  3. Levin A, Tonelli M, Bonventre J, et al. Global kidney health 2017 and beyond: a roadmap for closing gaps in care, research, and policy. Lancet. 2017;390:1888-917.

  4. Coresh J. Update on the Burden of CKD. J Am Soc Nephrol. 2017;28(4):1020–1022.

  5. National Kidney Foundation. Chronic kidney disease. Verfügbar auf: https://www.kidney.org/atoz/content/about-chronic-kidney-disease. Accessed in February 2024.

  6. Yim HE, Yoo KH. Obesity and chronic kidney disease: prevalence, mechanism, and management. Clin Exp Pediatr. 2021;64(10):511-518.

  7. Levin A, Tonelli M, Bonventre J, et al. Global kidney health 2017 and beyond: a roadmap for closing gaps in care, research, and policy. Lancet. 2017;390:1888-917.

  8. Wang V, et al. LE. Semin Nephrol. 2016;36(4):319-30 NHS: Chronic Kidney Disease. Verfügbar auf: https://www.nhs.uk/conditions/kidney-disease/. Accessed in February 2024.

  9. NHS: Chronic Kidney Disease. Diagnosis. Verfügbar auf: https://www.nhs.uk/conditions/kidney-disease/diagnosis/. Accessed in February 2024.

  10. KDIGO Executive Committee, Kidney International 2024; 105 (4S):117–314

  11. GBD Chronic Kidney Disease Collaboration, Lancet, 2020;395(10225);709-733