Mammalian Expertise

Your partner in mammalian cell cultures

Among the constantly growing market of biopharmaceuticals, monoclonal antibodies derived from mammalian cell culture account for a share of approximately 50%. Boehringer Ingelheim’s exceptional development and manufacturing expertise is not only limited to this dominating molecule format but covers diverse parts derived from CHO cells. We're proud to be one of the leaders in this key technology, with a history of success that includes 28 mammalian derived market products. As your one-stop partner for mammalian drug substance and drug product, we offer fast and tailored transfers for your unique needs. Our global network for mammalian cell culture manufacturing spans three continents, demonstrating our commitment to being your global partner. Experience the scale of our 15,000 L commercial manufacturing capabilities, designed to meet your high-volume needs.

Spanning three continents - your global network for mammalian cell culture manufacturing

With roughly 430,000 L of commercial mammalian drug substance capacity distributed between the USA (Fremont California), Germany (Biberach), Austria (Vienna) and China (Shanghai) our global network for mammalian cell culture manufacturing is waiting for you.
These cGMP facilities are licensed by the EMA, FDA & MHLW and show our unwavering commitment to reliable high-quality clinical and commercial supply.

Your one-stop partner for mammalian drug substance and drug product

Looking back at 40+ years of experience we are known for our extensive upstream, downstream and aseptic filling know-how, fast and tailored transfers, effective launch preparation and regulatory support. Our mammalian product expertise encompasses monoclonal antibodies, fusion proteins, antibody fragments, complex antibodies, enzymes, and other recombinant proteins.
Totalling over 60 different biopharmaceuticals and over 80 different processes for manufacturing (pre-)clinical material.

All analytical methods in-house

To ensure adherence to the highest quality standards that we are known for, we have all analytic capabilities in-house and perform GMP batch release testing for guaranteed product safety. Our methods portfolio comprises raw material qualification and testing, including in-depth IPC, which determines the product quality, as well as several methods to separate, specify, and quantify desired molecules and potential impurities.

Mammalian thought leadership

We are proud to be one of the thought leaders in the mammalian cell culture space. Take a look at our featured expert content pieces on mammalian cell culture or adjacent topics.

Building your future on our 40+ years history

The last 40 years are a testament for our long-standing and in-depth experience of both development and manufacturing of biopharmaceuticals, with over 60 biopharmaceuticals produced in our global manufacturing network.
Blending our experience with our broad commercial expertise, our development capabilities, and our state-of -the-art facilities, we can offer the whole value chain: from early stage, to launch, to commercial supply. This makes us your one-stop partner for mammalian drug substance and drug product.

In short, we are the ideal partner in mammalian technologies

• Tailored transfers
• Upstream and downstream processing
• Launch preparation and regulatory support
• Clinical and commercial supply
• GMP facilities licensed by EMA, FDA & MHLW
• All analytic capabilities inhouse
• GMP batch release testing
• Manufacturing of Fab fragment, Fc fusion proteins, TandAb, Ig DART, and further complex biologics like bi- or multispecific mAbs