Schizophrenia

Schizophrenia affects approximately 24 million people worldwide and is characterized by three symptom domains: positive and negative symptoms and cognitive symptoms. Positive symptoms, which include hallucinations and delusions, are most widely known and may be treated with established antipsychotics. Negative symptoms, such as reduced emotion, lack of motivation, and cognitive symptoms that affect problem-solving, attention, and memory, also significantly impact people’s lives. Yet, there are no approved pharmacological options for negative and cognitive symptoms.