NASH

Nonalcoholic fatty liver disease (NAFLD), a condition in which excess fat builds up in the liver, is the most common cause of liver disease in the U.S., affecting about 1 in 4 adults. Its symptoms are often silent, making it difficult to diagnose. Approximately 12-14% of people with NAFLD have a more aggressive form known as nonalcoholic steatohepatitis (NASH), which can progress to advanced liver fibrosis, cirrhosis or liver cancer. The prevalence of NASH has been estimated to range up to 6.4 million people in the U.S. NASH is more common in, but not limited to, people with metabolic disorders such as type 2 diabetes and obesity, with prevalence rates between 25-30% in people with obesity and approximately 30-40% in those living with type 2 diabetes. NASH is among the top causes of liver cancer and the second most common indication for liver transplantation in the U.S.